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Thrombotic Stroke In Sickle Cell Disease

Thrombotic strokes are strokes that occur in sickle cell disease patients which are caused by a thrombus (blood clot) that develops in the arteries which supply blood directly to the brain. Sickle cell disease patients could develop thrombotic stroke when they have a high cholesterol level, a case of diabetes, and also an underlying disease called atherosclerosis. 

Atherosclerosis is the buildup of fats and lipids inside the walls of blood vessels. In a thrombotic stroke, the blood clot or thrombus blocks the blood flow to a part of the brain, causing the brain cells in that area to quickly quit function and die. 

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Photo Credit: Sickle Cell Disease News

A thrombotic is a type of ischemic stroke that makes up about eighty percent of strokes in sickle cell disease patients. A thrombotic stroke may be called a cerebral thrombosis, a cerebral infarction, or a cerebral infarct.  Thrombotic strokes are divided into two categories based on the size of the area of blockage within the brain: large vessel thrombosis and small-vessel thrombosis. 

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Photo Credit: Nature

Large vessel thrombosis occurs only and majorly in larger blood vessels that supply blood in the arteries of the brain. They are the carotid arteries or the middle cerebral artery. Large vessel thrombotic stroke causes typical substantial symptoms and long-term effects such as aphasia (trouble with one’s language) or hemiparesis (weakness of one side of the body).

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Photo Credit: Nationwide Children’s Hospital

Small vessel thrombotic stroke occurs mainly when the blood flow is blocked to a small and also deep penetrating arterial blood vessel. This type of stroke is also known as a lacunar stroke or subcortical stroke. A small vessel thrombus can also result in a brainstem stroke. Small vessel thrombotic strokes are usually small in size, affecting only a limited area of the brain. 

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Photo Credit: SpringerLink

With dependency on the area impacted by a small vessel thrombotic stroke, it can produce substantial handicaps if it impacts a region of the brain that is responsible for important and noticeable physical or cognitive abilities. 

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Photo Credit: Wiley Online Library

Content created and supplied by: Dr-Kikiope (via Opera News )


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