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Erythroid Bone Marrow Hyperplasia In Sickle Cell Disease

Erythroid bone marrow hyperplasia is commonly known to be the term erythroid dysplasia which is a sickle cell disease condition that is seen by the immaturity or lack of substantial growth of the red blood cells which are present in the bone marrow, and also being found to be abnormal in size of cells and number of cells. 

Erythroid bone marrow hyperplasia or erythroid dysplasia may be caused by the deficiency of vitamin person, or chemotherapy, or a sign of refractory anemia, which is called myelodysplastic dysplasia. Erythroid precursors tend to have megaloblastic features being larger than the normoblasts cells. Erythroid cells differ from hematopoietic stem cells that reside within specific niches. 

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Photo Credits: ResearchGate

Related conditions with erythroid bone marrow hyperplasia are anemia, myelodysplastic syndrome, iron deficiency, megaloblastic anemia, and pancytopenia. Anemia is a condition in which the blood does not have enough or sufficient healthy red blood cells due to the early death of the sickled red blood cells in sickle cell disease patients. The symptoms of anemia include; weakness, fast heart rate, shortness of breath, amongst others. 

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Photo Credits: Journal of Hematology & Oncology

A myelodysplastic syndrome is a clinical group of disorders caused by the disruption and interruption of the blood cells production in the body. Symptoms of the myelodysplastic syndrome are; anemia, bleeding, fatigue, etc. Iron deficiency is a condition described by the presence of low or too little iron in the body. Symptoms of iron deficiency are; fast heart rate, shortness of breath, fatigue, etc. 

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Photo Credits: Mayo Clinic

Megaloblastic anemia is a type of macrocytic anemia. It is a type of anemia that is seen by the restriction and undersupply of oxygen due to a defective red blood cell. Pancytopenia is a medical condition in which there is a reduction in the number of red blood cells RBCs and white blood cells WBCs, as well as a reduction in the platelets. 

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Photo Credits: ScienceDirect

The treatment involves restoring the normal function of the bone marrow by the use of Ferrum containing medications, vitamins, and blood or plasma transfusions. 

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Photo Credits: C&EN

Content created and supplied by: Dr-Kikiope (via Opera News )

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