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Sickle Cell Disease In Hyperplasia

Hyperplasia is seen as an increased number of cells resulting in the increase in mass of tissue or organ affected in sickle cell disease patients. Hyperplasia is a condition that allows for the enlargement of an organ or tissue caused by an increase in the amount of organic tissue that results from cell proliferation. 

Hyperplasia takes place in the cells if they are capable of dividing. Hyperplasia is caused by a chronic inflammatory response, hormonal dysfunctions, the proliferation of basal layer of the epidermis to compensate for skin loss and compensation for damage or disease elsewhere in the body. The type of hyperplasia is dependent on the area of the body being affected and the cause. 

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Photo Credit: ResearchGate

The types are physiologic hyperplasia and pathologic hyperplasia. Physiologic hyperplasia is the type of hyperplasia that occurs due to the growth of completely normal cells and is then further divided into two, hormonal hyperplasia and compensatory hyperplasia. Hormonal hyperplasia is the proliferation of glandular epithelial cells of female breast tissue at puberty and lactation or breastfeeding. Compensatory hyperplasia is the regeneration of the liver after partial hepatectomy. 

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Photo Credit: ResearchGate

Pathologic hyperplasia is a type of hyperplasia that results from abnormal or precancerous changes and is also further divided into three, endometrial hyperplasia, benign prostatic hyperplasia due to excess of estrogen hormones, and skin warts due to viral infection. 

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Photo Credit: RSNA Journals

Endometrial hyperplasia which is a subtype of physiologic hyperplasia is divided into four namely; simple endometrial hyperplasia, complex endometrial hyperplasia, simple atypical endometrial hyperplasia, and complex atypical endometrial hyperplasia. The treatment of hyperplasia generally is dependent on the cause and nature of the growing cells being detected and seen. 

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Photo Credit: RSNA Journal

The treatment of endometrial hyperplasia is a progestin that can be taken in different forms like a pill, shot (injection shot), vaginal cream, or an intrauterine device. Hyperplasia is a common disease in women with sickle cell disease 

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Photo Credit: RSNA Journals

Content created and supplied by: Dr-Kikiope (via Opera News )

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