Addison disease (or Addison's disease) is adrenocortical insufficiency due to the destruction or dysfunction of the entire adrenal cortex. It affects glucocorticoid and mineralocorticoid function. The onset of disease usually occurs when 90% or more of both adrenal cortices are dysfunctional or destroyed.
A disorder in which the adrenal gland don't produce enough hormones. insufficient amounts of the hormone cortisol and sometimes aldosterone, too. When the body is under stress (e.g. fighting an infection), this deficiency of cortisol can result in a life threatening Addisonian crisis characterised by low blood pressure.
Causes of Addison disease.
Tuberculosis (TB) is the most common cause of Addison's disease worldwide, but it's rare in the UK. TB is a bacterial infection that mostly affects the lungs but can also spread to other parts of your body. It can cause Addison's disease if it damages your adrenal glands.
Is Addison's disease serious?
Addison's disease is a rare but serious adrenal gland disorder in which the body can't produce enough of two critical hormones, cortisol and aldosterone. Patients with Addison's diseasewill need hormone replacement therapy for life.
Survival rate of someone with Addison's disease.
The mean ages at death for females (75.8 years) and males (64.8 years) were 3.2 and 11.2 years less than the estimated life expectancy. Conclusion: Addison's disease is still a potentially lethal condition, with excess mortality in acute adrenal failure, infection, and sudden death in patients diagnosed at young age.
How is Addison's disease diagnosed?
Test can measure your blood levels of sodium, potassium, cortisol and adrenocorticotropic hormone (ACTH), which stimulates the adrenal cortex to produce its hormones. A blood test can also measure antibodies associated with autoimmune Addison's disease.
Treatment of Addison disease.
Treatment usually involves corticosteroid (steroid) replacement therapy for life. Corticosteroid medication is used to replace the hormones cortisol and aldosterone that your body no longer produces. It's usually taken in tablet form 2 or 3 times a day.
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