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Bone Marrow Hyperplasia In Sickle cell disease

Bone marrow hyperplasia is a condition of sickle cell disease patients that also leads to anemia and it also has a resultant effect of weakening the skeletal tissue by widening the medullary cavities, thereby replacing trabecular bone and thinning cortices. 

Bone marrow is the part of the human body responsible for the new production of bone marrow stem cells and other substances which would, in turn, produce blood cells such as the red blood cells RBCs, white blood cells WBCs, and other blood components, it is a spongy like substance found in the center of bones. 

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Photo Credit: RSNA Journals

 Bone marrow hyperplasia is described as the noticeable increase in the number of hematopoietic cells found in the bone marrow of sickle cell disease patients. It may involve all or individual hematopoietic cell lines. Bone marrow hyperplasia has been linked to cell proliferation, cell cycle, cell growth, pathogenesis, and pigmentation of the cells. 

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Photo Credit: RSNA Journals

Bone marrow hyperplasia is associated with other underlying diseases such as anemia, leukemia, hyperplasia, neoplasms, and myeloid leukemia.  The causes of bone marrow hyperplasia are; hemorrhage, hemolytic anemia, intrinsic bone marrow disease (including aplastic anemia, and malignant neoplasms), and anemia of chronic disease. Bone marrow hyperplasia would occur when the bone marrow is affected or diseased. 

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Photo Credit: RSNA Journals

The symptoms of bone marrow hyperplasia are; fatigue, shortness of breath, rapid or irregular heart rate, pale skin, frequent or prolonged infections, unexplained or easy bruising, nose bleeding, bleeding gums, and prolonged bleeding from cuts. Erythroid bone marrow hyperplasia or erythroid dysplasia is a form of bone marrow hyperplasia that is described by the immaturity of red blood cells in the bone marrow that are abnormal in size and in number. 

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Photo Credit: RSNA Journals

Erythroid bone marrow hyperplasia can be caused by a vitamin deficiency or chemotherapy, or it may be a sign of refractory anemia, which is a myelodysplastic syndrome.  The best form of treatment for bone marrow hyperplasia is a bone marrow or cord blood transplant in sickle cell disease patients. 

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Photo Credit: Hindawi

Content created and supplied by: Dr-Kikiope (via Opera News )

RSNA

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