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Understanding Sickle Cell Disease

‘S’ is the sickle cell gene with conformational changes that confirms a person positive for sickle cell disease, ‘C’ represents another cell with conformational changes that shows a defect in the red blood cell.

Hemoglobin SC is a derivative from hemoglobin S and hemoglobin C, and the patient inherits both of the genes, one from each parent, which the hemoglobin S is heterozygous (and dominant in an expression), and hemoglobin C is homozygous (and recessive in an expression). Hemoglobin SC is a type of sickle cell disease, which affects the shape of red blood cells, causing a dysfunction of the normal condition of the body.  

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Photo Credit: Labpedia

Hemoglobin ‘SC’ is different in nature when compared to hemoglobin ‘SS’ Hb SS, in that it does not show any symptoms until the teenage years, unlike hemoglobin SS which shows symptoms at five months of age. Hb SS is a blood disorder that is genetic and congenital; it is caused by mutations in the gene that tells the body how to produce hemoglobin, it is a milder form of sickle cell disease. 

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Photo Credit: Medindia

It is diagnosed by a screening test called the newborn screening. Patients with Hb SC are either affected minimally or severely, and it is differentiated by the occurrence and severity of symptoms. 

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Photo Credit: MomJunction

Hb SC may produce the complications of sickle cell disease in relation to Hb SS, but there it is less frequent and severe when compared with Hb SS. Research shows that patients with Hb SC live longer than patients with Hb SS, and the median life span in women is 68 years and in men is 60 years for those infected with Hemoglobin SC.  


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Photo Credit: Mount Sinai

Some patients with Hb SC have normal hemoglobin levels and show fewer episodes of sickle cell disease than patients with Hb SS. Its treatment is dependent on the frequency and severity of episodes; it is treated with hydroxyurea with 10mg/kg/day and is then extended to 5mg/kg/day at eight (8) weeks intervals to reach a maximum dose. There is also a drop in the defense or fighting cells of the body 

Content created and supplied by: Dr-Kikiope (via Opera News )

Hemoglobin SC Labpedia SS Sickle Cell Disease

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