Manchester United and Chelsea both suffered defensive injuries in the Premier League's final round, with Luke Shaw and Reece James failing to last 45 minutes for their respective clubs on Saturday.
Two England international full-backs had to be replaced before half-time as Ole Gunnar Solskjaer and Thomas Tuchel were forced into tactical and selection adjustments.
The Red Devils and the Blues will now await updates from their medical services regarding the severity of the accidental blows.
Shaw had played every minute of the 2021-22 United States Premier League campaign ahead of a home date with Aston Villa. That record is now over, with the 26-year-old having had a muscle complaint during his last outing.
Shaw had had a rough afternoon before being substituted as Matty Cash gave him plenty of trouble and the Red Devils left-back was booked for an awkward challenge.
Within five minutes of this warning, he was forced to leave the pitch. With only 34 minutes on the clock, it became evident that Shaw was unable to continue and had to be replaced by Diogo Dalot.
Shaw's international colleague also suffered a frustrating outing on home soil.
The Chelsea star lined up on the right wing for Tuchels' side in a heavyweight cash with Manchester City at Stamford Bridge.
However, he had to hold out for less than half an hour before his manager was forced to change.
Following a collision with Jack Grealish, James struck the bridge several times before finally giving way to an ankle problem. His place was taken by Thiago Silva, with Cesar Azpilicueta moved from a center berth and into a flank role.
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