The Gunners will be looking to improve on their quarter-final appearance last season, and they will be confident going into this one after winning two games in a row and keeping two key clean sheets.
Mikel Arteta will want to rotate his squad and offer his younger players some playing time, but he will also be looking ahead to Sunday's derby against Tottenham.
Here is my predicted line-up for the game.
GOALKEEPER & DEFENDERS:
Bernd Leno (GK): Expect Leno to be given another chance to show himself after being benched for the past two games by the brilliant Aaron Ramsdale.
Chambers (RB): Chambers, another player who has been on the fringes recently, has struggled for minutes this year and might be used more here.
Pablo Mari (CB): Mari is vying for a starting place again, and a strong showing here will be essential.
Holding (CB): Arteta will want to keep both Ben White and Gabriel fresh for the Spurs game, so don't expect to see them here.
Taveres (LB): Tierney has been suffering from cramps and is unlikely to play. However, young Tavares is very certain to start.
Sambi Lokonga (DM): With Granit Xhaka out, Elneny injured, and Thomas Partey still working on his fitness, Lokonga should take this slot.
Maitland-Niles (DM): Maitland-Niles will need to develop quickly if he wants to be known as a central midfielder.
Nicolas Pepe (RM): Pepe is likely to be rested by Arteta, but a lack of options may force him to start.
Martinelli (LM): Martinelli, who has been an unused substitute for the past three games, is ready to return to the starting line-up.
Smith Rowe (AM): Smith Rowe was substituted on the hour mark against Burnley, so he'd be fit enough for this match.
Lacazette (CF): Lacazette has struggled for minutes, so he'll be hoping for a start and to add to the goal he scored against West Bromwich Albion in the second round.
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