The Blues will host Dean Smith's side to Stamford Bridge for the second time this season, this time around in the cup as they both look to progress into the fourth round.
It's been an unbeaten start to the season so far for Chelsea, and that has include fitness problems and injury for the Premier League giants.
The Blues were without Christian Pulisic and Edouard Mendy on Sunday against Tottenham Hotspur due to injury, and Tuchel gave an update on their current situation during his press conference on Tuesday.
Mendy will miss the Aston Villa game, while no return date has been made on Pulisic.
"Mendy can't play, he wasn't in training. We will try to integrate him tomorrow in training and hopefully Thursday's training but not yet, Tuchel told BT Sport.
"We had some big games, we'll make some changes, and we will take the chance to give some minutes and competition to players who are missing playing time at the moment".
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