Chelsea suffered their first defeat this season in a 1-0 loss to Manchester City on Saturday.
Juventus are aiming to extend their unbeaten run against Chelsea to four, and a fourth victory in five matches in all competition this season.
Though they had a poor start to the season, Juventus have since bounced back with successive 3-2 league victories against Spezia and Sampdoria.
Despite their disappointing domestic start, Juventus won their opening Champions League match in Group H earlier this month, securing a comfortable 3-0 victory away against Swedish outfit Malmo.
The Italian giants will be up against Chelsea, who have lost only three of their last 32 Champions League group stage games.
Head to head?
Juventus emerge winner in their last meeting with Chelsea, claiming a 3-0 home victory during the 2012-13 group stage.
In the past, Juventus have won seven times against a European Cup holder. The last time the Old Ladies lost a Champions League game against an English opposition was a 2-1 defeat at home to Manchester United in November 2018.
Chelsea on their end, have lost their last four Champions League fixtures against an Italian opposition - they lost to AC Milan in the 2009/2010 season before suffering a defeat to Napoli in the 2011/2012 season. Those were followed by losses to Juventus and Roma in the 2012/2013 and 2017/2018 seasons.
Juventus forwards Alvaro Morata and Paolo Dyabala limped off the pitch against Sampdoria with respective hamstring and thigh injuries, with the latter leaving the pitch in tears.
For Chelsea, they are set to be without right wing-back Reece James who was forced off in the first half against Man City after twisting his ankle.
Chelsea skipper Cesar Azpilicueta is expected to replace the 21-year-old, while Thiago Silva is set to join Andreas Christensen and Antonio Rudiger in the back three.
Venue and kick off time?
The mouth watering encounter will be played at the Allianz Arena in Turin with kick off scheduled for 8pm.
Jesus Gil from Spain will be in charge of the game on Wednesday.
Perin; Danilo, Chiellini, Bonucci, Sandro; Bentancur, Locatelli, Ramsey; Chiesa, Kean, Kulusevski
Mendy; Christensen, T. Silva, Rudiger; Azpilicueta, Kovacic, Jorginho, Alonso; Havertz, Lukaku, Werner
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