Ole Gunnar Solskjaer side have been in stunning form since the league restarted recording only one draw which came against Southampton and winning the remaining games.
Manchester United will make the trip to Wembley stadium on Sunday to play Chelsea.
Recall that the left-back was injured against Southampton on Monday. He was replaced by Brandon Williams.
While Williams was also ruled out of the win at Crystal Palace on Thursday.
Speaking during his press conference,Ole Gunnar Solskjaer said: “Luke will be out. I can't see him recovering. Brandon will hopefully be okay, he'll try to join in training today with his eye. We'll see if he can see the ball when he comes in! He should be fine.”
Ole Gunnar Solskjaer had to call on Alex Tuanzebe in the full back position to fill the void in the mid week 2-0 win against Crystal Palace at Selhurst park.
The manager believes he has to access the fitness of others players ahead of the clash on Sunday.
He said: “We’ve not seen a lot of them [the players] because we’re just coming up to a training session now.
"But I’d rather have this game than not have it. We can’t say it [the scheduling] has been unkind, it is what it is and, when you get the opportunity to play a semi-final, you’ll squeeze that in even if you have to play on the same day.”
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