The Catalan based club would be hoping to improve on their weak defence having conceded eight goals in their last three matches in all competitions.
The Barcelona head coach is expected to name a strong line up for the crunch encounter against Madrid.
The Catalan giants Barcelona ladies are the clear favourites to get all the maximum three points at the Juan Cruyff Stadium.
The Catalan giants Barcelona ladies currently sit 1st position on the Spanish Women's Premier Division ahead of their tricky encounter against Madrid Feminine.
The Barcelona ladies have amassed 84 points with +131 goal difference after 29 matches played in the league.
Here is the confirmed Spanish Women's Premier Division standings;
The Spanish giants Barcelona feminine currently sit 1st position on the standings having amassed 84 points so far this season.
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