The Blues have been without Mateo Kovacic for the past eight games with a hamstring injury, and he has been ruled out of the derby.
Meanwhile, Andreas Christensen suffered a hamstring injury of his own against Manchester City, and he is also sidelined for the game.
Speaking in a press conference, Thomas Tuchel said that the duo could return in time for the FA Cup final against Leicester City on Saturday.
The Blues are currently fourth in the league standings with 64 points, six ahead of fifth-placed West Ham United with a superior goal difference.
They are in a good position to qualify for the Champions League, and a victory against their London rivals should secure their berth.
The reverse meeting ended in a disappointing 3-1 loss at the Emirates Stadium. The Blues will be aiming to avenge the result tomorrow.
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