Luke Shaw who picked an ankle injury and was been replaced by Brandon Williams, who also had a cut above his eyes before Southampton equalize in stoppage time.
Timothy Fuso-Mensah was handed his first start in three years to fill the left back position, and he earned the praised of Ole Gunnar Solskjear after the game.
However, Williams cut is expected to healed in time to face the Blues come Sunday, wish will see him return to line-up.
Scott McTominay replaced the Serbian Nemanja Matic against Crystal Palace, but he was too slow with his passes and thereby been replaced by Nemanja Matic at halftime. Which give the Serb the advantage to start against his former team.
In midfield we will see the same combination of Paul Pogba and Bruno Fernandes, and a front three of Marcus Rashford, Anthony Martial and Mason Greenwood.
Sergio Romero has been preferred between the sticks throughout the FA Cup competition so far this campaign.
However, with it being just two potential games away from lifting the trophy, Solskajer could opt for his star stopper David De Gea instead for this one.
Below is how the line-up would look like.
Content created and supplied by: Kingtexzy (via Opera News )
Opera News is a free to use platform and the views and opinions expressed herein are solely those of the author and do not represent, reflect or express the views of Opera News. Any/all written content and images displayed are provided by the blogger/author, appear herein as submitted by the blogger/author and are unedited by Opera News. Opera News does not consent to nor does it condone the posting of any content that violates the rights (including the copyrights) of any third party, nor content that may malign, inter alia, any religion, ethnic group, organization, gender, company, or individual. Opera News furthermore does not condone the use of our platform for the purposes encouraging/endorsing hate speech, violation of human rights and/or utterances of a defamatory nature. If the content contained herein violates any of your rights, including those of copyright, and/or violates any the above mentioned factors, you are requested to immediately notify us using via the following email address operanews-external(at)opera.com and/or report the article using the available reporting functionality built into our Platform See More