Here we give you the preview, team news, prediction as well as the kick-off time for the match.
The pair are both still down with muscular injuries that kept them out of the midweek Champions League clash with RB Leipzig.
Striker Shane Long is a boast for Southampton as he will be available for them after completing his isolation following a positive covid-19 test.
Midfielder Will Smallbone is back in full team training after eight months on the sidelines with a serious knee injury but will not be available as is not expected to be rushed back into match action.
Winger Theo Walcott and midfielder Stuart Armstrong are still sidelined with calf muscle issues.
Man city are the favorite to win the encounter following their impressive wins in the mid week Champions League group stage match against RB Leipzig.
Kick-off time is 15:00 GMT.
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