Despite fielding a much-changed XI for the game, Ole Gunnar Solskjaer's side lost 1-0 at home to West Ham on Wednesday night. However, when it comes to Premier League affairs, the story is entirely different.
Here is my predicted line-up for the game.
GOALKEEPER & DEFENDERS:
De Gea (GK): Last Saturday, he was the hero of United's 2-1 league victory over the Hammers, saving Mark Noble's last-minute penalty. He's more than deserving of a second chance.
Varane (CB): His Red Devils career has got off to a good start, with him appearing as composed as expected and even picking up an assist.
Maguire (CB): The United captain has gained the reputation of being one of Europe's best central defenders in recent months, and he will return to the backline.
Shaw (LB): Since regaining his form last year, he hasn't slowed down and is a tremendous addition to Solskjaer's team.
Wan-Bissaka (RB): Although he had a poor start to his Champions League campaign against Young Boys, he has looked good in domestic play thus far.
Fred (CM): Many doubts have been raised about Fred in the United midfield, and while he clearly has a flaw, Solskjaer is set to keep the Brazilian in his engine room.
McTominay (CM): McTominay, who came back from a groin injury to play the entire 90 minutes in his team's 2-1 triumph at the London Stadium on Saturday, should be alongside him.
Fernandes (AM): Fernandes is so important to this team that it seems unimaginable to have a Manchester United line-up without him.
Greenwood (RW): Greenwood is expected to return to the fold for this match after impressing with a cameo in midweek. Although he hasn't scored this month, he has three Premier League goals to his name, so don't count him out.
Ronaldo (CF): Will he be able to keep this magical comeback going? Possibly.
Pogba (LW): Pogba didn't get an assist last time out, but he'll always be capable of delivering some awe-inspiring magic to add to his seven assists this season.
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