Ben Chilwell's first goal for his country got England up and running when VAR overruled an offside call in the 18th minutes of the game before Bukayo Saka benefitted from an exquisite pass from the standout Phil Foden to double the advantage before the break.
Tammy Abraham then marked his first England appearance in 11 months with a close-range finish in the 59th minutes from Jadon Sancho's second assist of the night.
James Ward-Prowse followed up his saved penalty which had been awarded by history-making female referee Kateryna Monzul - to match the scoreline from September's reverse fixture at Wembley.
Jack Grealish - who had won the penalty - then made it five when he followed Chilwell in scoring his first international goal in the 86th minutes of the game latching onto a long-range pass from goalkeeper Sam Johnstone, as England swept aside opponents ranked 156th in the world rankings.
The victory - celebrated by around 1,000 England supporters inside the Estadi Nacional d'Andorra, who were able to support their side away from home for the first time in almost two years.
Fans leave England on the brink of World Cup qualification with just three games left to play, including Tuesday's game with Hungary at Wembley.
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